Publications
2026
Strilets TI, Dremel SE, Garcia-Blanco MA. YBX1 regulates RNA polymerase III transcripts to prevent inflammation. Proc Natl Acad Sci U S A. 2026 Sep;123(35):e2605741123. doi: 10.1073/pnas.2605741123. Epub 2026 Aug 21. PMID: 42627844; PMCID: PMC13535238.
García-Ariza LL, Padilla-Sanabria L, García-Blanco MA, Castaño-Osorio JC. Experimental validation of compound 3md, identified in silico, demonstrates antiviral effect on DENV2 by intervention in the replicative phase. Virology. 2026 May;618:110838. doi: 10.1016/j.virol.2026.110838. Epub 2026 Feb 16. PMID: 41722289.
2025
Sánchez-Montejo J, Teodosio C, Strilets T, López-Abán J, Manzano-Román R, Pozo J, Martin S, Silos L, Trujillo I, García-Blanco MA, Vicente B, Muro A. Harnessing mRNA technology against Fasciola hepatica: Immunological insights from a fatty acid binding protein vaccine. Front Immunol. 2025 Nov 25;16:1693674. doi: 10.3389/fimmu.2025.1693674. PMID: 41376640; PMCID: PMC12687294.
Strilets T, Garcia-Blanco MA. Y-box binding proteins in immunity and RNA virus infection. Microbiol Mol Biol Rev. 2025 Dec 18;89(4):e0019124. doi: 10.1128/mmbr.00191-24. Epub 2025 Sep 23. PMID: 40985650; PMCID: PMC12713401.
Zhang T, Altouma V, Sommers JA, Dumm AJ, Kennedy D, Xia H, Yang M, Fullenkamp CR, Huang SN, Xue Y, Su S, Shen W, Haren CE, Kulikowicz T, Pommier Y, Schneekloth JS Jr, Garcia-Blanco MA, Brosh RM Jr, Wang W. Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis. J Biol Chem. 2025 Sep;301(9):110547. doi: 10.1016/j.jbc.2025.110547. Epub 2025 Aug 5. PMID: 40752578; PMCID: PMC12423399.
Fernández-García L, Garcia-Blanco MA. Host RNA-binding proteins and specialized viral RNA translation mechanisms: Potential antiviral targets. Antiviral Res. 2025 May;237:106142. doi: 10.1016/j.antiviral.2025.106142. Epub 2025 Mar 13. PMID: 40089163.
Roa-Linares VC, Betancur-Galvis LA, González-Cardenete MA, Garcia-Blanco MA, Gallego-Gomez JC. Broad-spectrum antiviral ferruginol analog affects the viral proteins translation and actin remodeling during dengue virus infection. Antiviral Res. 2025 May;237:106139. doi: 10.1016/j.antiviral.2025.106139. Epub 2025 Mar 4. PMID: 40043781.
Sánchez-Montejo J, Strilets T, Manzano-Román R, López-Abán J, García-Blanco MA, Vicente B, Muro A. Design and Expression of Fasciola hepatica Multiepitope Constructs Using mRNA Vaccine Technology. Int J Mol Sci. 2025 Jan 30;26(3):1190. doi: 10.3390/ijms26031190. PMID: 39940957; PMCID: PMC11818309.
2024
Kuzmin IV, Soto Acosta R, Pruitt L, Wasdin PT, Kedarinath K, Hernandez KR, Gonzales KA, Hill K, Weidner NG, Mire C, Engdahl TB, Moon WJ, Popov V, Crowe JE Jr, Georgiev IS, Garcia-Blanco MA, Abbott RK, Bukreyev A. Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine. Nat Commun. 2024 Jul 30;15(1):6421. doi: 10.1038/s41467-024-50774-3. PMID: 39080316; PMCID: PMC11289437.
Banerjee S, Nagasawa CK, Widen SG, Garcia-Blanco MA. Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing. Nucleic Acids Res. 2024 Aug 12;52(14):8534-8551. doi: 10.1093/nar/gkae431. PMID: 38801080; PMCID: PMC11317157.
Nagasawa CK, Bailey AO, Russell WK, Garcia-Blanco MA. Inefficient recruitment of DDX39B impedes pre-spliceosome assembly on FOXP3 introns. RNA. 2024 Jun 17;30(7):824-838. doi: 10.1261/rna.079933.123. PMID: 38575347; PMCID: PMC11182011.
2023
Banerjee S, Galarza-Muñoz G, Garcia-Blanco MA. Role of RNA Alternative Splicing in T Cell Function and Disease. Genes (Basel). 2023 Sep 30;14(10):1896. doi: 10.3390/genes14101896. PMID: 37895245; PMCID: PMC10606310.
Nagasawa CK, Garcia-Blanco MA. Early Splicing Complexes and Human Disease. Int J Mol Sci. 2023 Jul 13;24(14):11412. doi: 10.3390/ijms241411412. PMID: 37511171; PMCID: PMC10379813.
Hirano M, Galarza-Muñoz G, Nagasawa C, Schott G, Wang L, Antonia AL, Jain V, Yu X, Widen SG, Briggs FBS, Gregory SG, Ko DC, Fagg WS, Bradrick S, Garcia-Blanco MA. The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate. Elife. 2023 Jun 1;12:e76927. doi: 10.7554/eLife.76927. PMID: 37261960; PMCID: PMC10234631.
Yeh SC, Strilets T, Tan WL, Castillo D, Medkour H, Rey-Cadilhac F, Serrato-Pomar IM, Rachenne F, Chowdhury A, Chuo V, Azar SR, Singh MK, Hamel R, Missé D, Kini RM, Kenney LJ, Vasilakis N, Marti-Renom MA, Nir G, Pompon J, Garcia-Blanco MA. The anti-immune dengue subgenomic flaviviral RNA is present in vesicles in mosquito saliva and is associated with increased infectivity. PLoS Pathog. 2023 Mar 30;19(3):e1011224. doi: 10.1371/journal.ppat.1011224. PMID: 36996041; PMCID: PMC10062553.
Sehrawat S, Garcia-Blanco MA. RNA virus infections and their effect on host alternative splicing. Antiviral Res. 2023 Feb;210:105503. doi: 10.1016/j.antiviral.2022.105503. Epub 2022 Dec 23. PMID: 36572191; PMCID: PMC9852092.
2022
Garcia-Blanco MA, Ooi EE, Sessions OM. RNA Viruses, Pandemics and Anticipatory Preparedness. Viruses. 2022 Sep 30;14(10):2176. doi: 10.3390/v14102176. PMID: 36298729; PMCID: PMC9611157.
Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA. Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells. RNA. 2022 Aug;28(8):1058-1073. doi: 10.1261/rna.079137.122. Epub 2022 May 25. PMID: 35613883; PMCID: PMC9297843.
Fagg WS, Liu N, Braunschweig U, Pereira de Castro KL, Chen X, Ditmars FS, Widen SG, Donohue JP, Modis K, Russell WK, Fair JH, Weirauch MT, Blencowe BJ, Garcia-Blanco MA. Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate. Nucleic Acids Res. 2022 May 20;50(9):5313-5334. doi: 10.1093/nar/gkac327. PMID: 35544276; PMCID: PMC9122611.
Diosa-Toro M, Kennedy DR, Chuo V, Popov VL, Pompon J, Garcia-Blanco MA. Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly. mBio. 2022 Feb 22;13(1):e0019622. doi: 10.1128/mbio.00196-22. Epub 2022 Feb 22. PMID: 35189699; PMCID: PMC8903895.
2021
Liao KC, Chuo V, Fagg WS, Modahl CM, Widen S, Garcia-Blanco MA. The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response. Nucleic Acids Res. 2021 Sep 27;49(17):10034-10045. doi: 10.1093/nar/gkab732. PMID: 34428287; PMCID: PMC8464043.
Liao KC, Garcia-Blanco MA. Role of Alternative Splicing in Regulating Host Response to Viral Infection. Cells. 2021 Jul 8;10(7):1720. doi: 10.3390/cells10071720. PMID: 34359890; PMCID: PMC8306335.
Muruato AE, Fontes-Garfias CR, Ren P, Garcia-Blanco MA, Menachery VD, Xie X, Shi PY. Author Correction: A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation. Nat Commun. 2021 Jun 22;12(1):4000. doi: 10.1038/s41467-021-24287-2. Erratum for: Nat Commun. 2020 Aug 13;11(1):4059. doi: 10.1038/s41467-020-17892-0. PMID: 34158492; PMCID: PMC8218561.
Schott G, Galarza-Muñoz G, Trevino N, Chen X, Weirauch MT, Gregory SG, Bradrick SS, Garcia-Blanco MA. U2AF2 binds IL7R exon 6 ectopically and represses its inclusion. RNA. 2021 Apr 16;27(5):571-583. doi: 10.1261/rna.078279.120. PMID: 33568552; PMCID: PMC8051268.
——————————————————————————————————————————————————————————
A comprehensive list of Dr. Mariano A. Garcia Blanco’s publications can be found here:
https://pubmed.ncbi.nlm.nih.gov/?sort=date&term=Garcia-Blanco+MA&cauthor_id=40985650